Zakai or Zakkai () is a Hebrew surname. Notable people with the surname include:
David Zakai (1886 – 1978), member of the Second Aliyah, Hebrew teacher, Histadrut leader, Jewish journalist and publicist Johanan ben Zakai, Mishnah rabbi Mira Zakai (1942–2019), Israeli contralto Moshe Zakai (born 1926), Israeli scientist Shafrira Zakai (born 1932), Israeli voice actress and translator Shai Zakai Shmuel Zakai (born 1963), Israeli general Yehezkel Zakai (born 1932), Israeli politician
See also
Ben Zakkai Zakai Zeigler (born 2002), American basketball player
he:זכאי