Büyükdere is a Turkish word meaning "big creek" and may refer to:
Places Büyükdere, Hasankeyf, a village in the Hasankeyf district of Batman Province, Turkey Büyükdere, Koçarlı, a village in the Koçarlı district of Aydın Province, Turkey Büyükdere, Pasinler Büyükdere, Pazaryolu Büyükdere, Sarıyer, a quarter of Sarıyer district in Istanbul Province, Turkey Büyükdere Avenue, a major street in the European part of Istanbul, Turkey
Other uses TCG Büyükdere (P-128), a former minesweeper of the Turkish Navy