MSE may refer to:

Education Master of Science in Engineering, a university degree Master of Science in Software Engineering, a college degree in software engineering Master of Software Engineering, a university degree; for example at the Information and Communications University

Science, technology and engineering Manned Spaceflight Engineer, an astronaut in the United States Air Force's Manned Spaceflight Engineer Program Mars Surface Exploration Materials Science and Engineering Maunakea Spectroscopic Explorer, a planned renovation of the Canada–France–Hawaii Telescope Maximum spacing estimation, in statistics Mean squared error, in statistics Mechanically stabilized earth Mental status examination, used by clinicians to assess aspects of a patient's mental state Mercury Surface Element, the lander portion of BepiColombo space mission MSE (centrifuges), Measuring and Scientific Equipment, manufacturer of laboratory centrifuges Selenomethionine, a naturally occurring amino acid

Computing Message Stream Encryption, a BitTorrent protocol encryption Media Source Extensions, a W3C standard for JavaScript media streaming Metasearch engine, a search engine that consolidates results from other search engines Microsoft Security Essentials, a free antivirus software Mobile Subscriber Equipment, a tactical communications system formerly used by units such as the 17th Signal Battalion (United States)

Stock exchanges Macedonian Stock Exchange Madras Stock Exchange Madrid Stock Exchange Malawi Stock Exchange Malta Stock Exchange Mongolian Stock Exchange Montenegro Stock Exchange Montreal Stock Exchange

Other Kent International Airport, by IATA airport code Mississippi Export Railroad, common freight carrier in Mississippi, by reporting mark Martha Stewart Everyday, a mass-market brand of Martha Stewart Living Omnimedia sold through Kmart Medical Science Educator, academic journal Melbourne String Ensemble Micro and Small Enterprises Ministry of Sustainability and the Environment, in Singapore MoneySavingExpert.com, a British consumer finance information website Monumental Sports & Entertainment, American sports and venue management company Odakyu 60000 Series MSE, a train part of the Romancecar family