William E. Breese Sr. House is a historic house located at 674 Biltmore Avenue in Asheville, Buncombe County, North Carolina.

Description and history It was built in 1891 by architect Charles B. Leonard, and is a -story, rectangular timber-framed dwelling in the Queen Anne style. It features an off-center entrance tower with a steeply pitched pyramidal roof. The building housed a sanatorium, called Sherwood Sanatorium, from around 1927 to 1932. After 1939, the building housed a tourist home known as Cedar Crest.

It was listed on the National Register of Historic Places on April 28, 1980.

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