Reuven Kalisher (25 April 1828 – 20 August 1896), resident of Zhytomir, was a Jewish doctor and Hebrew-language literist.
Vitiligo and Tzaraath Kalisher maintained the view that the Torah-mentioned tzaraath is not leprosy but in fact vitiligo, Yehuda L. Katzenelson quotes Kalisher's view in his work on medicinal talmudic work (הרפואה וחכמת התלמוד berlin, 1928).
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Literary works Natural works and medicine (Hebrew) Warsaw, 1862.