HDL may refer to one of the following:
Science and technology Hardware description language, in computer engineering Handle System identifier for information resources High-density lipoprotein, complex particles Huntington's disease-like syndromes, a family of genetic neurological diseases
Other uses GE HDL, a diesel engine Harry Diamond Laboratories, a U.S. Army laboratory Headstone Lane railway station (National Rail station code), London, England Les Hurlements d'Léo, an alternative rock band from France