The 1888 Harvard Crimson football team represented Harvard University in the 1888 college football season. They finished with a 12–1 record. The team outscored its opponents 631–32, including a 102–0 victory over Amherst on November 3. The Crimson suffered its sole loss, to Princeton, losing by an 18–6 score on November 17. Two days later, Harvard defeated the Penn by a 48–0 score.
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