VPX is a computer bus standard.

VPX may also refer to:

Vpx, Viral Protein X, a protein VPX Sports, and VPX, brand names of Vital Pharmaceuticals Victorian Power Exchange, established by the Government of Victoria, Australia VPX, video technology by NewBlue Vodafone VPx, see HTC Blue Angel

See also OpenVPX, an Industry Working Group of defense contractors