Roussopoulos or Rhousopoulos () is a Greek surname and may refer to:
Athanasios Rhousopoulos (1823–1898), Greek archaeologist Athanasios Roussopoulos (1903–1983), Greek scientist Carole Roussopoulos (1945–2009), Swiss film director and feminist Dimitrios Roussopoulos (born 1936), political activist, ecologist, and writer Theodoros Roussopoulos (born 1963), Greek politician