Spike is a nickname of the following people:
Arts and entertainment Spike Feresten (born 1964), American television writer and talk show host Spike Jones (1911–1965), American musician and bandleader Spike Jonze (born 1969), American filmmaker and photographer Spike Lee (born 1957), American filmmaker Spike Milligan (1918–2002), Irish satirist, creator of The Goon Show Spike Robinson (1930–2001), jazz musician Spike Spencer (born 1968), American voice actor Spike Stent (born 1965), English record producer and mixing engineer Spike Trotman, American cartoonist and publisher Spike Wells (born 1946), English jazz drummer and priest
Sports Spike Albrecht (born 1992), American college basketball player Spike Gehlhausen (born 1954), American race car driver Spike Jones (American football) (born 1947), American former National Football League punter Spike McRoy (born 1968), American golfer Spike Pola (1914–2012), Australian rules footballer Spike Carlyle (born 1993), American MMA fighter
Military Cedric Howell (1896–1919), Australian First World War flying ace William H. P. Blandy (1890–1954), US Navy admiral William Eckert (1909–1971), US Air Force lieutenant general and fourth Commissioner of Major League Baseball William W. Momyer (1916–2012), US Air Force general and World War II flying ace
Politics Spike Cohen (born 1982), American libertarian vice presidential candidate, political activist, entrepreneur, and podcaster
Fictional characters Spike (Peanuts), Snoopy's brother in the Peanuts comic strip Spike the Bulldog (disambiguation) Spike the Dragon, a character from My Little Pony: Friendship is Magic Spike Spiegel, a character from Cowboy Bebop Spike Pratt, a character from Buffy the Vampire Slayer and Angel Spike, multiple characters from Marvel Comics Spike, a bulldog from Tom and Jerry Spike, a Koopa enemy and a workman from Mario Spike McNeil, a character from You, Me and the Apocalypse Spike, a Stegosaurus from Land Before Time