James Caine (1908–1971) was an English professional footballer.
James Caine may also refer to:
Jim Caine (jazz pianist) (1926–2018), Manx jazz pianist, radio presenter and raconteur James Caine, candidate in South Tyneside Council election, 2004
See also James Cain (disambiguation) James Caan (disambiguation) James Cane (disambiguation) Jim Kane (disambiguation) James Cayne businessman