GLS may refer to:

Science and technology GBAS landing system, an aircraft landing system GLS light bulb, a type of light bulb used for general lighting service Generalized least squares, in statistics Global location sensor Glutaminase, a type of enzyme often abbreviated GLS Glutaminase kidney isoform, specific enzyme encoded by the gene GLS Gray leaf spot, a fungal plant disease Guided local search, a search algorithm

Organisations General Logistics Systems, a Dutch logistics company Genesis Lease (NYSE: GLS), a former Bermudan aircraft leasing company Government Legal Service, former name of a UK Government group University of Chicago Graduate Library School Glasgow Literary Society, Scotland Global Linguist Solutions, an American translation company GLS Bank, a German ethical bank GLS University, in Ahmedabad, India

Events Games, Learning & Society Conference Georgetown Leadership Seminar Global Leaders' Summit

Places Glaisdale railway station (Station code), in England Gloucestershire, England Scholes International Airport at Galveston (IATA and FAA LID codes), Texas, US

Other uses Guy L. Steele Jr. (born 1954), American computer scientist Mercedes-Benz GLS, an automobile