D'Onofrio or Donofrio is an Italian surname derived from the given name Onofrio. Notable people with the name include:
D'Onofrio Brian D'Onofrio, American psychologist Carmen D'Onofrio (born 1974), Canadian soccer player Carol D'Onofrio (1936–2020), American public health researcher Daniele D'Onofrio (born 1993), Italian long-distance runner Denis D'Onofrio (born 1989), Italian footballer Dominique D'Onofrio (1953–2016), Italian football coach Elizabeth D'Onofrio (born 1957), American actress Francesco D'Onofrio (born 1939), Italian politician and academic François D'Onofrio (born 1990), Belgian footballer Giovanni D'Onofrio (born 1998), Italian rugby player Katerina D'Onofrio (born 1978), Peruvian actress Mark D'Onofrio (born 1969), American college football coach and former player Nicola D'Onofrio (1943–1984), Italian Camillian monk Terryana D'Onofrio (born 1997), Italian karateka Vincent D'Onofrio (born 1959), American actor
Donofrio
Beverly Donofrio (born 1950), American writer and teacher Edward Donofrio (born 1951), American fencer Heather Daly-Donofrio (born 1969), American golfer Nick Donofrio (born 1945), American scientist and engineer
See also D'Onofrio (brand) Onofrio Onofri