Simionescu is a Romanian-language surname. Notable people with the surname include:
Adrian Simionescu, Romanian vocalist Grigore Simionescu, Romanian general Ion Th. Simionescu, Romanian geologist Mariana Simionescu, Romanian tennis player Nicolae Simionescu, Romanian physician Vlăduț Simionescu, Romanian judoka
See also Dan Simonescu, also known as Simionescu Simionești (disambiguation)