Maria Santos may refer to:
María Santos, Argentine actress of the 1940s Maria Santos (swimmer) (born 1978), Portuguese swimmer Maria Amélia Santos (born 1952), Portuguese politician María Santos Corrales (1797–1881), Peruvian woman María Santos Gorrostieta Salazar (1976–2012), Mexican physician and politician Maria Antónia Almeida Santos, Portuguese politician María Antonia Santos Plata (1782–1819), Neogranadine peasant, rebel leader and heroine María Clemencia de Santos (born 1955), First Lady of Colombia María Isabel Pérez Santos (born 1966), Mexican politician Maria Santos (All My Children), a fictional character from the ABC soap opera All My Children