SPLA may refer to:
Sahrawi People's Liberation Army, the army of the Sahrawi Arab Democratic Republic, previously the armed branch of the Polisario Front Socialist Propaganda League of America, former group within the ranks of the Socialist Party of America, 1915–1919 South Sudan People's Defense Forces, formerly Sudan People's Liberation Army SPLA-Nasir and SPLA-United, a Sudanese breakaway faction formed in 1991 Services Provider License Agreement, created by Microsoft to allow service providers to host software services for their customers SHARE Program Library Agency, a repository of contributed programs for IBM computers.
See also Spla/ryanodine receptor domain and socs box containing 3, a protein encoded by the SPSB3 gene