Matthew Gregory may refer to:
Matthew Gregory (deacon) (1680–1777), member of the Connecticut House of Representatives from Norwalk Matthew Gregory (attorney) (born 1968), former Northern Mariana Islands Attorney General Matt Gregory (hiker) (born 1978) Matthew Gregory (speaker), speaker of the House of Assembly of Jamaica, 1705–1706 Matthew Gregory (politician, died 1779) (1693–1779), planter and politician in Jamaica