Simeone is an Italian surname. Notable people with the surname include:
Carmelo Simeone (1934–2014), Argentine football player Diego Simeone (born 1970), Argentine football manager and former player Gianluca Simeone (born 1998), Argentine football player Harry Simeone (1911–2005), American musician Giovanni Simeone (born 1995), Argentine football player Giuliano Simeone (born 2002), Argentine football player Lee Jason Simeone (born 1980), English musician Osvaldo Simeone, American engineer
See also Simeoni