Gayle is a surname. Notable people with the surname include:
Charles Gayle (1939–2023), American jazz musician Chris Gayle (born 1979), West Indian cricketer Crystal Gayle (born 1951), Country and pop singer Dwight Gayle (born 1990), English footballer Gordon D. Gayle (1917–2013), American brigadier general and historian Helene D. Gayle (born 1955), American physician Howard Gayle (born 1958), English footballer John Gayle (Alabama politician) (1792–1859), American politician from Alabama John Gayle (footballer) (born 1964), English footballer Kavan Gayle, Jamaican politician Marcus Gayle (born 1970), English-born Jamaican footballer Michelle Gayle (born 1971), English actress and singer Mike Gayle (born 1970), British author and freelance journalist Peta-Gaye Gayle (born 1979), Jamaican sprinter Roddy Gayle Jr. (born 2003), American basketball player Sarah Ann Haynsworth Gayle (1804–1835), diarist; wife of John Shaun Gayle (born 1962), American football player Tajay Gayle (born 1996), Jamaican long jumper W. A. Gayle (1896–1965), American politician William D. Gayle (1859–1936), American businessman and politician