2-Tetralone is an organic chemical compound with the molecular formula C10H10O. This colourless oil is an intermediate in organic synthesis. It is a ketone derivative of tetralin, a hydrogenated derivative of naphthalene.
History and synthesis The compound was first obtained by Eugen Bamberger and Wilhelm Lodter in 1893 by dehydrohalogenation of 3-chloro-2-tetralol with hot alkali.
2-Tetralone may be prepared by reductive cleavage of 2-naphthyl ethers.M. D. Soffer, M. P. Bellis, Hilda E. Gellerson, and Roberta A. Stewart "β-Tetralone" Org. Synth. 1952, 32, 97
Applications 2-Tetralone is an intermediate in the synthesis of a variety of pharmaceutical drugs including L-687,384, nepinalone, napamezole, spirodone, and trioxifene.
See also
1-Tetralone
References