Interstate 76 or I-76 may refer to:
Transportation Interstate 76 (Colorado–Nebraska) (I-76), US Interstate 76 (Ohio–New Jersey) (I-76), running through Pennsylvania, US
Other uses Interstate '76, a vehicular combat video game for Windows
See also Japanese submarine I-76, later renamed Japanese submarine I-176 Ilyushin Il-76 (Il-76), a Soviet aircraft Illinois Route 76 (IL 76), Illinois, US