James Sykes may refer to:
James Sykes (Continental Congress) (1725–1792), American lawyer and Continental Congressman James Sykes (governor) (1761–1822), American physician and Acting Governor of Delaware Rod Sykes (James Rodney Winter Sykes, born 1929), Canadian politician, mayor of Calgary, Alberta James Sykes (Canadian football) (born 1954), former CFL running back Jim Sykes (born 1950), journalist James Sykes (cricketer) (born 1992), Leicestershire County Cricket Club cricketer