Frank or Frankie Byrne may refer to:

Frank M. Byrne (1858–1927), American politician Frank Byrne (Irish nationalist) (1848–1894), an instigator of the Irish National Invincibles Frank Byrne (Australian politician) (c. 1836–1923), NSW politician Frank Byrne (rugby union), (born 1938), Irish rugby union player Frankie Byrne (Gaelic footballer) (1924–2019), played for Meath GAA Frankie Byrne (EastEnders), fictional character Frankie Byrne (broadcaster) (1922–1993), public relations consultant and broadcaster

See also Francis Byrne (disambiguation)