Jesús Castillo may refer to:
Chucho Castillo (1944–2013), Mexican world champion boxer Jesús Castillo (composer) (1877–1946), Guatemalan composer Jesús Castillo (Mexican footballer) (born 1988), Mexican footballer Jesús Castillo (Peruvian footballer) (born 2001), Peruvian footballer Jesús Castillo Jr. (born 1960), Puerto Rican wrestler