Losh is a surname. Notable people with the surname include:
Elizabeth Losh, American media theorist James Losh (1763–1833), English lawyer, reformer and unitarian Sarah or Sara Losh (1785–1853), English architect and designer William Losh (1770–1861), English chemist and industrialist credited with introducing the Leblanc process
LoSH also stands for: Legion of Super-Heroes