Francisco Santos may refer to: Francisco Dos Santos (born 1974), Brazilian footballer Francisco Santos (swimmer, born 1962), Angolan/Portuguese swimmer, artist and writer, also known as Xesko Francisco Santos (swimmer, born 1998), Portuguese swimmer Francisco Santos (baseball) (born 1974), former Major League Baseball outfielder Francisco Santos (footballer) (1904–?), Portuguese footballer Francisco Santos Calderón (born 1961), Colombian politician and journalist Francisco Santos Leal (born 1968), Spanish mathematician Francisco Cabrera Santos (1946–2010), mayor of Valencia, Carabobo, Venezuela Francisco Santos, Piauí, a municipality in the state of Piauí, Brazil Francisco O. Santos (1892–1983), Filipino nutritionist and biochemist