Theodote or Theodota (, "divine gift") is the feminine form of Theodotus and may refer to:

Theodote (courtesan), 5th-century BC courtesan in ancient Greece, mentioned in Memorabilia of Xenophon Theodota of Philippi (died 318), Greek harlot and Christian martyr Theodota of Nicaea (4th century), Christian woman martyred with her sons Theodota (concubine), concubine of the Lombard king Cunipert (), later a nun Theodota of Constantinople (died 735), Byzantine woman executed during the Byzantine Iconoclasm Theodote (empress), the second consort of the Byzantine emperor Constantine VI ()

Theodota or Theodote is also the Syriac masculine form of the name Theodotus and may refer to:

Theodotus of Amida (died 698), Syrian Orthodox holy man

See also Acraea theodote, a synonym of the butterfly Acraea andromacha