Saybrook may refer to:
Places Saybrook Colony (1635–1644), later merged with what is now the State of Connecticut Old Saybrook, Connecticut Saybrook, Illinois, a village Saybrook Township, Ashtabula County, Ohio and the unincorporated crossroads of Saybrook in the township
Education Saybrook College, one of the 14 residential colleges at Yale University in New Haven, Connecticut Saybrook University (originally the Humanistic Psychology Institute, and later Saybrook Graduate School and Research Center), a California university specializing in psychology, organizational systems, and human science
See also Marty Saybrooke, a fictional character