ISD may refer to:
Schools United States Independent school district, a type of school district Illinois School for the Deaf, Jacksonville, Illinois Independence Public School District, headquartered in Independence, Missouri Indiana School for the Deaf, Indianapolis, Indiana Interboro School District, a school district headquartered in Prospect Park, Pennsylvania, in the Philadelphia area Issaquah School District, a school district headquartered in Issaquah, Washington
Elsewhere International School of Dakar, Senegal International School Dhaka, Bangladesh International School of Düsseldorf, Germany International School of Dongguan, Guangdong, China International School of Design, Valenciennes, France
Organizations Industrial Union of Donbas, Ukrainian corporation Information Services Department of the Hong Kong Government Information Services Division of NHS National Services Scotland Institute for Strategic Dialogue, London-based international affairs think tank Internal Security Department (Singapore) of the Republic of Singapore Internal Security Department (Brunei) of Brunei Team ISD, professional cycling team
Other Inhibited sexual desire, old name for hypoactive sexual desire disorder In-school detention Instructional systems design, also known as instructional design International Subscriber Dialling, also known as International Direct Dialling Integrated Surface Database, global surface weather observations