Harald Jockusch (born 1939 in Frankfurt am Main) is a German biologist and artist with the alias Hal Jos.

Scientific focus

Scientific contributions

RNA viruses During the analysis of the host defence discovery of temperature sensitive (ts) ts TMV coat proteins of tobacco mosaic virus (TMV)Jockusch, H. (1964). In vivo- und in vitro-Verhalten temperatursensitiver Mutanten des Tabakmosaikvirus. Z Vererbungsl. 1964 Dec 30;95:379-82. Jockusch, H. (1966). Temperatursensitive Mutanten des Tabakmosaikvirus. I. In vivo-Verhalten. Z Vererbungsl. 98, 320-343Jockusch, H. (1966). Temperatursensitive Mutanten des Tabakmosaikvirus. II. In vitro-Verhalten. Z Vererbungsl. 98, 344-362

Relationship between the structural stability and amino acid replacements of mutant TMV coat proteins (collaboration with H.-G. Wittmann and Brigitte Wittmann-Liebold)Jockusch H. Stability and genetic variation of a structural protein. Naturwissenschaften. 1968 Nov;55(11):514-8. No abstract available.

More recent work: ts TMV coat proteins as models for misfolded (toxic) proteins in the host plant cellJockusch H, Wiegand C. Misfolded plant virus proteins: elicitors and targets of ubiquitylation. FEBS Lett. 2003 Jun 19;545(2-3):229-32. and in transfected animal cells

Synthesis of active phage Q beta replicase in a cell-free systemHappe M, Jockusch H. Cell-free protein synthesis resulting in active phage Qbeta replicase. Nat New Biol. 1973 Oct 3;245(144):141-3.

Developmental biology and molecular pathology

A mouse mutant, the so-called ADR mouse, was characterized as genetic model for human myotonia type Becker.Füchtbauer EM, Reininghaus, J, Jockusch, H. Developmental control of the excitability of muscle: transplantation experiments on a myotonic mouse mutant. Proc Natl Acad Sci USA. 1988 Jun; 85(11):3880-4. As in the human Becker and Thomsen myotonias, a strongly reduced chloride conductance of the muscle fibre membrane causes hyperexcitability of the muscle fibre, leading to episodic stiffness.Mehrke G, Brinkmeier H, Jockusch H. The myotonic mouse mutant ADR: electrophysiology of the muscle fiber. Muscle Nerve. 1988 May; 11(5):440-6. In the ADR mouse the mutated gene was identified as coding for the then newly discovered muscular chloride channel (in collaboration with the group of Thomas Jentsch).Steinmeyer K, Klocke R, Ortland C, Gronemeier M, Jockusch H, Gründer S, Jentsch TJ. Inactivation of muscle chloride channel by transposon insertion in myotonic mice. Nature. 1991 Nov 28;354(6351):304-8. ) These results lead to the identification of the human myotonia gene mutations in which either cause recessive Becker or dominant Thomsen myotonia depending on the change in the amino acid sequence.Koch MC, Steinmeyer K, Lorenz C, Ricker K, Wolf F, Otto M, Zoll B, Lehmann-Horn F, Grzeschik KH, Jentsch TJ. The skeletal muscle chloride channel in dominant and recessive human myotonia. Science. 1992 Aug 7;257(5071):797-800.

Biomechanical analyses of the consequence of the deficiencies in the cytoskeletal proteins dystrophin (the protein deficient in Duchenne muscular dystrophy)Menke A, Jockusch H. Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse. Nature. 1991 Jan 3;349(6304):69-71.) and desmin in isolated muscle fibres and muscle cell culturesWieneke S, Stehle R, Li Z, Jockusch H. Generation of tension by skinned fibers and intact skeletal muscles from desmin-deficient mice. Biochem Biophys Res Commun. 2000 Nov 19;278(2):419-25. [PubMed – indexed for MEDLINE

Biochemical investigations into the neurodegeneration using the wobbler mouse model for ALS. The responsible gene was identified as Vps54, a gene involved in protein sorting during the retrograde vesicle transport within the cell (in collaboration with the group of Miriam Meisler, Ann Arbor)Schmitt-John T, Drepper C, Mussmann A, Hahn P, Kuhlmann M, Thiel C, Hafner M, Lengeling A, Heimann P, Jones JM, Meisler MH, Jockusch H. Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse. Nat Genet. 2005 Nov;37(11):1213-5. Epub 2005 Oct 23.

Discovery of a feedback mechanism between the extracellular protease ADAM 8 and the inflammation signalling molecule tumour necrosis factor alpha (TNFalpha) (with Jörg-Walter Bartsch)Bartsch JW, Wildeboer D, Koller G, Naus S, Rittger A, Moss ML, Minai Y, Jockusch H. Tumor necrosis factor-alpha (TNF-alpha) regulates shedding of TNF-alpha receptor 1 by the metalloprotease-disintegrin ADAM8: evidence for a protease-regulated feedback loop in neuroprotection. J Neurosci. 2010 Sep 8;30(36):12210-8. doi: 10.1523/JNEUROSCI.1520-10.2010.

Proteomics of tissues affected by hereditary neuromuscular diseases in the mouse model; analysis of the testis in the wobbler ALS mouse modelJockusch H, Holland A, Staunton L, Schmitt-John T, Heimann P, Dowling P, Ohlendieck K. Pathoproteomics of testicular tissue deficient in the GARP component VPS54: The wobbler mouse model of globozoospermia. Proteomics. 2013 Sep 30. doi: 10.1002/pmic.201300189. [Epub ahead of print]

Morphogenesis of cardiacJockusch H, Füchtbauer EM, Füchtbauer A, Léger JJ, Léger J, Maldonado CA, Forssmann WG. Long-term expression of isomyosins and myoendocrine functions in ectopic grafts of atrial tissue. Proc Natl Acad Sci U S A. 1986 Oct;83(19):7325-9. Eberhard D, Jockusch H. Patterns of myocardial histogenesis as revealed by mouse chimeras. Dev Biol. 2005 Feb15;278(2):336-46. and skeletal muscle and of the pancreasEberhard D, Jockusch H. Clonal and territorial development of the pancreas as revealed by eGFP-labelled mouse chimeras. Cell Tissue Res. 2010 Oct;342(1):31-8. doi: 10.1007/s00441-010-1028-y. Epub 2010 Aug 29.

Theoretical models Topology of the metazoan body planJockusch H, Dress A. From sphere to torus: a topological view of the metazoan body plan. Bull Math Biol. 2003 Jan;65(1):57-65.

Dynamics of frequency of family names after imposing the rule "rare wins"Jockusch H, Fuhrmann A (2010). „Selten gewinnt" – Rare wins. Changes in the frequencies of family names as a consequence of rational choice. Beiträge zur Namenforschung 45(2): 127–142)

See also List of publications during Jockusch's time as professor at Bielefeld University (1981–today) Jockusch H Publications in Pubmed Biomed Experts ResearchGate Hal Jos Hal Jos Art Hal Jos Portfolio Hal Jos Mygall

References