Margaret Hughes (c. 1630–1719) was an English actress; mistress of Prince Rupert of the Rhine.

Margaret Hughes may also refer to:

Margaret Hughes (bowls), lawn bowler from Zambia Margaret Hughes (Los Angeles) (1826–1915), first woman member of the Los Angeles City Board of Education Margaret Hughes (sportswriter) (1919–2005), English sportswriter Margaret Hughes, Miss Australia 1949 Margaret Hughes, a character in The Wiser Sex