Crispino is an Italian-language occupational surname and name, literally meaning "cobbler".
The surname may refer to: Armando Crispino (1924–2003), Italian film director and screenwriter Diamante Crispino (born 1994), Italian footballer Jerry L. Crispino (1930–2009), American politician Jesús Eduardo Corso Crispino (1920–2012), Uruguayan lawyer, agricultural journalist and writer Mike Crispino, American sportscaster