DiDonato (or Di Donato) is an Italian surname. Notable people with the surname include:
Andrew DiDonato (born c. 1987), American college football coach Anthony DiDonato (1911–1989), former Democratic member of the Pennsylvania House of Representatives Daniele Di Donato (born 1977), Italian football manager Emily DiDonato (born 1991), American model Giacomo Di Donato (born 1988), Italian footballer Greg DiDonato (born 1963), American politician Jacques Di Donato (born 1942), French musician and improviser Joyce DiDonato (born 1969), American operatic mezzo-soprano Melissa Di Donato, American businesswoman Pietro di Donato (1911–1992), American writer and bricklayer