Frutos is a Spanish surname. Notable people with the surname include:
Alexandre Frutos, French football player Alexis Frutos Vaesken, Paraguayan diplomat Francisco Frutos, Spanish politician Javier de Frutos, Venezuelan choreographer Juan Manuel Frutos, President of Paraguay Nicanor Duarte Frutos, President of Paraguay Nicolás Frutos, Argentine football player Noelia Frutos, Spanish politician Pilar Frutos, Paraguayan team handball player