Great Siege may refer to:
Great Siege of Gibraltar, 1779–1783, an unsuccessful attempt by Spain and France to capture Gibraltar from Britain Great Siege of Malta, 1565, an unsuccessful attempt by the Ottoman Empire to capture Malta from the Order of Saint John Great Siege of Montevideo, 1843–1851, during the Uruguayan Civil War Great Siege of Scarborough Castle, 1645, during the English Civil War