Depew may refer to:
Places United States Depew, Iowa, an unincorporated community Depew, Missouri, an unincorporated community Depew, New York, a village Depew, Ohio, an unincorporated community Depew, Oklahoma, a town
People with the surname Chauncey Depew (1834–1928), American politician and lawyer Hap Depew (1887–1940), American cinematographer Joseph Depew (1912–1988), American actor and director Diezel Depew, Mayor, City of Edgewater, FL