Weis is a German surname, often occurring as a spelling variant of Weiss, from the German word weiß meaning "white", potentially referring to skin or hair complexion or a location name. The surname may in some cases have also come to be from a medieval German nickname for someone considered wise.

Notable people with this surname include:

Aaron and Adam Weis, American child actors and school teachers Al Weis (born 1938), baseball player Alexandrea Weis, American novelist André Weis (born 1989), German soccer player Anna Weis (born 1998), American sailor Bernhard Weis (born 1976), German soccer coach Butch Weis (1901–1997), American baseball player Carlo Weis (born 1958), Luxembourgish soccer player Charlie Weis (born 1956), American football coach Charlie Weis Jr. (born 1993), American football coach Christian Weis (born 1968), German tennis player Danny Weis (born 1948), American guitarist for Iron Butterfly and Rhinoceros Dominique Weis, Canadian scientist Don Weis (1922–2000), American director Ellen Havre Weis (1957–2021), American historian Flemming Weis (1898–1981), Danish composer Frédéric Weis (born 1977), French basketball player Frederick Lewis Weis (1895–1966), American historian Gary Weis, American filmmaker Heinz Weis (born 1963), German athlete Heidelinde Weis (1940–2023), Austrian actress Indira Weis (born 1979), German actress and singer Jakob Weis (1879–1948), German priest Jessica M. Weis (1901–1963), American politician Jody Weis (born 1957), American police officer John Ellsworth Weis (1892–1962), American painter John Harvey Weis (1911–1992), American politician Joseph F. Weis Jr. (1923–2014), American judge Judith Weis (born 1941), American marine biologist Kaleb Weis, American politician Karel Weis (1862–1944), Czech composer Kira Weis (born 2004), German long-distance runner Margaret Weis (born 1948), American writer Martin Weis (born 1970), German rower Melissa Weis (born 1971), American discus thrower Michelle Weis (born 1997), Danish ice hockey player Nicolaus von Weis (1796–1869), German bishop Paul Weis (1907–1991), Austrian lawyer Petra Weis (born 1957), German politician Samuel Washington Weis (1870–1956), American painter Shirley Weis, American business executive Sosthène Weis (1872–1941), Luxembourgish artist Thea Weis (1924–1999), Austrian actor Tobias Weis (born 1985), German soccer player

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