Claypool is a surname. Notable people with the surname include:
Chase Claypool (born 1998), Canadian-born American football player Forrest Claypool, American politician Horatio C. Claypool, U.S. Congressman Harold K. Claypool, U.S. Congressman Les Claypool, American bassist, singer Philip Claypool, American country music artist Ralph Claypool, American football player William Claypool, American racehorse trainer