The Premio 40 Principales for Best Spanish Group was an honor presented annually at Los Premios 40 Principales. For the 2011 edition this award was merged with the Best Solo category into the Best Artist/Group award.

Year Winner Other nominees 2006El Canto del Loco 2007Pereza 2008El Canto del Loco 2009Pereza 2010Maldita Nerea