List of bus routes in Onondaga County, New York

The following routes are operated by CNYRTA's CNY Centro division, in and around the City of Syracuse and Onondaga, Cayuga, and Oswego counties.

Base Route Terminals Major streets Areas & Landmarks served8 SyrculatorCentro Transit HUB 8: W. Washington & S. Clinton Streets Salina Street, Franklin Street, Washington Street, S. State Street, Harrison Street Onondaga County Central Library, Clinton Square, Franklin Square, City Hall, City & County Government buildings, War Memorial, Everson Museum Free Downtown Syracuse circulator 10 S. Salina StCentro Transit HUB 110: Valley Plaza South Salina Street One Centro Center, Upstate University Hospital, Valley Plaza, Clary Middle School, Green Hills Farms Shopping Center, Nedrow 410: Conklin Ave16 N. Salina StCentro Transit HUB 16: Regional Transportation Center & Destiny USA North Salina Street, 1st North Street, Buckley Road, 7th North Street, Old Liverpool Road, Electronics Parkway Little Italy, Regional Transportation Center, Destiny USA, Lockheed Martin, Liverpool 116: 7th North Street 216: Electronics Parkway 316: Electronics Parkway via Old Liverpool Road20 James StCentro Transit HUB 20: Eastwood – Lamson Street James Street, Midler Avenue, Molloy Road Bryant & Stratton College, Lincoln Middle School, Eastwood, Hancock Airpark 120: Midler Ave 220: Hancock Airpark 21 James St - SunnycrestCentro Transit HUB 21: Sunnycrest Road James Street, Teall Avenue, Sunnycrest Road Bryant & Stratton College, Lincoln Middle School, Henninger High School, Shop City, Eastwood 121: Sunnycrest Road via Shop City22 James St - Rt. 298Centro Transit HUB 22: Rt. 298/Carrier Circle James Street, Thompson Road, Fly Road Bryant & Stratton College, Lincoln Middle School, Eastwood, Carrier Circle 122: East Syracuse via Fly Road23 James St - East SyracuseCentro Transit HUB 23: East Syracuse James Street, Manlius Street, Fremont Road, Kirkville Road Bryant & Stratton College, Lincoln Middle School, Eastwood, East Syracuse, Minoa 123: East Syracuse Walmart 323/323X: Minoa26 South AveCentro Transit HUB 26: Corcoran High School South Avenue, Bellevue Avenue, West Onondaga Avenue & West Onondaga Street, Valley Drive, Onondaga Road, Velasko Road Corcoran High School, Community General Hospital, Onondaga Community College, Van Duyn Nursing Home, Onondaga Hill 226X, 426, 526 - trips continue on South Avenue and do not serve Bellevue or Onondaga Avenues 126: Upstate Hospital at Community General 226/226X: Onondaga Community College 326: High Acres via Onondaga Community College 426: Upstate Hospital at Community General via Valley Drive 526: Onondaga Community College via Valley Drive30 SU - WestcottCentro Transit HUB 130: Nottingham High School Irving Avenue, Waverly Avenue, Euclid Avenue, Westcott Street, East Genesee Street, Erie Boulevard East, Bridge Street University Hill, Upstate University Hospital, Syracuse University, Nottingham High School, Dewitt, East Syracuse 230: Menorah Park 330 Wegman’s Dewitt Park-N-Ride 530: East Syracuse Walmart36 CamillusCentro Transit HUB 36: Camillus West Genesee Street, South State Street, Erie Boulevard West Nation Grid, Westvale, Fairmount, West Genesee High School, Camillus Commons, Camillus 136: Camillus Commons38 Auburn - SyracuseCentro Transit HUB 138: Auburn, NY Grand Ave, Howlett Hill Road, Old Seneca Turnpike, Genesee Street Western Lights, Township 5, Camillus Commons, Marcellus, Welch Allyn, Auburn Auburn 238: Camillus Commons40 SU - HospitalsCentro Transit HUB 40: Syracuse University Adams Street, Irving Avenue, Waverly Avenue, Comstock Avenue, East Colvin Street, Brighton Avenue Upstate University Hospital, Syracuse University, Outer Comstock, Meadowbrook, Drumlins Country Club, Nob Hill Apartments, Iroquois Nursing Home 140: Thurber Street 240: Nob Hill 340: Drumlins College Place 340C: Drumlins43 Main CampusCollege Place 43: West Campus Irving Avenue, Waverly Avenue, East Fayette Street, East Genesee Street, Westcott Street, Flint Hall, Brewster-Boland Hall, Archbold Gym, Carrier Dome, SUNY ESF, Syracuse Stage, Schine Student Center, Bird Library Syracuse University campus shuttle route. Operates only when classes are in session August - May. Students and staff ride free 243 - Operates in counter-clockwise loop, serving Westcott Street, then East Genesee Street and West Campus 343 - Operates in clock-wise loop, serving East Genesee Street, then Westcott street 443 - After arriving at College Place, trips continue to South Campus 243: East Genesee & University Ave 343: Westcott Street & Euclid Avenue 443: The Warehouse44 Manley Field HouseCollege Place 44: Manley South Parking Lot Comstock Avenue, Small Road, Skytop Road, Slocum Drive, Lambreth Lane, Winding Ridge Road College Place, Manley Field House, Goldstein Student Center, Skyhall, Skytop Office Building Syracuse University campus shuttle route. Operates only when classes are in session August - May. Students and staff ride free. 344 - Select trips serve Skyhall both before and after serving the Skytop Office Building 244: Goldstein Student Center 344: Skytop 444: Small Road & Lambreth Lane45 SU - Destiny USACollege Place 45: Destiny USA Irving Avenue, Comstock Avenue, East Colvin Avenue, Jamesville Avenue, Brighton Avenue, Thurber Street College Place, Destiny USA, Manley Field House, SU Physical Plant, Clarendon Heights, Hidden Valley, Remington Gardens Syracuse University campus shuttle route. Operates only when classes are in session August - May. Students and staff ride free. 45 - Operates Saturdays, late afternoon & early evenings only 345 - Operates Weekdays, early & late mornings only 345: Thurber Street46 Liverpool - Rt. 57Centro Transit HUB 46: Wegmans – Route 31 South State Street, Old Liverpool Road, Route 57, Soule Road, Route 31, Route 481 Upstate University Hospital, Syracuse University, Destiny USA, Liverpool, Great Northern Mall, Oswego, Fulton 246/246X: Oswego Fulton 346: Oswego48 Liverpool - Morgan RdCentro Transit HUB 48: Grampian Road South State Street, Old Liverpool Road, John Glenn Boulevard, Route 57 Destiny USA, Liverpool, Bayberry, Wegmans Liverpool 148: Wegmans via Bayberry 248: Wegmans via John Glenn Boulevard50 Destiny USACentro Transit HUB 50: Destiny USA via I-81 South State Street, I-81, Solar Street, Park Street Franklin Square, Inner Harbor, Regional Transportation Center, Destiny USA 550: Destiny USA via Solar Street510 Tully - LaFayetteCentro Transit HUB 510: Tully Community Church Park-N-Ride Adams Street, Harrison Street, I-81, Route 11 SUNY Upstate Hospital, Tully, LaFayette 52 Court StCentro Transit HUB 52: Shop City North Salina Street, Townsend Street, Butternut Street, Park Street, Grant Boulevard, Court Street, Molloy Road Northside, Grant Middle School, Shop City, Henninger High School 152: Industrial Park 54 MidlandCentro Transit HUB 54: Matson South Salina Street, South Avenue, Midland Avenue, Ballantyne Road, Valley Drive, Seneca Turnpike One Centro Center, Shop Rite, Meachem Field, Valley Vista Apartments, Bernadine Apartments, Valley Plaza 254: Valley Plaza58 ParkhillCentro Transit HUB 58: Bishop Grimes High School Washington Street, Burnet Avenue, Thompson Road Midtown, Eastwood, Carrier Circle, East Syracuse62 FayettevilleCentro Transit HUB 62: Towne Center at Fayetteville East Genesee Street, I-690, I-481, Widewaters Parkway, Route 92, Route 257 Widewaters Parkway, Dewitt Wegmans Park-N-Ride, SUNY Upstate Hospital, Towne Center at Fayetteville, Northeast Medical Center, Fayetteville, Manlius 162: Manlius via I-690 & Widewaters Parkway 262: Manlius via East Genesee Street 262X: Manlius via I-481 & SUNY Upstate Hospital 362: Wegmans Dewitt Park-N-Ride via I-690 & Widewaters Parkway 462: Manlius via I-690 & I-48164 Western LightsCentro Transit HUB 64: Western Lights via West Onondaga Street Gifford Street, West Onondaga Street, Bellevue Avenue, Grand Avenue, Fay Road Near Westside, Western Lights Plaza, Taunton, Bishop Ludden High School 164: Bellevue Avenue via Western Lights 264: St. Camillus via West Onondaga Street 364: Western Lights via Grand Avenue 464: St. Camillus via Grand Avenue 68 E. Fayette - Erie BlvdCentro Transit HUB 68: Westmoreland Avenue East Fayette Street, Erie Boulevard East, Bridge Street Midtown, Rolling Green Estates, Erie Boulevard retail corridor, DeWitt, East Syracuse Walmart 168: Widewaters Parkway72 Townsend - E. ColvinCentro Transit HUB 72: Toomey Abbott Apartments Oakwood Avenue, Garfield Avenue, East Colvin Street, Comstock Avenue Pioneer Homes, Central Village, Almus Oliver Apartments, Manley Field House, Loretto & Iroquois Nursing Homes 172: Loretto Health & Rehab74 SolvayCentro Transit HUB 74: Solvay via Milton Avenue Gifford Street, Avery Avenue, Milton Avenue Near Westside, PSLA @ Fowler High School, Solvay 274: Solvay via Avery Avenue 374: Township 5 76 Salt SpringsCentro Transit HUB 76: Le Moyne College East Genesee Street, Salt Springs Road, Bridge Street Midtown, Eastside, Le Moyne College, DeWitt 176: Widewaters Parkway80 Grant BlvdCentro Transit HUB 80: Shop City James Street, Butternut Street, Grant Boulevard Northside, Eastwood, Shop City, Grant Village Apartments, Eastwood Homes 180: Taft & Dunlap Avenues82 BaldwinsvilleCentro Transit HUB 82: Baldwinsville – Spruce Street State Fair Boulevard, I-690, Downer Street Baldwinsville, Fairgrounds, Destiny USA. 682 - Regular service operates Saturday & Sunday only, Memorial Day – Labor Day. Special event service operates for events at the Lakeview Amphitheater. During the New York State Fair, service is replaced by various Park-N-Ride shuttles. 182: Baldwinsville – Mott Road via Indian Springs 682: Lakeview Park/Fairgrounds 84 MattydaleCentro Transit HUB 84: Brewerton Road Brewerton Road, Molloy Road, Allen Road, Chestnut Street Northside, Mattydale, Northern Lights Plaza, North Syracuse 184 Allen Road86 Henry Clay BlvdCentro Transit HUB 186: Wetzel Road via YMCA South State Street, I-81, Buckley Road, Taft Road, Henry Clay Boulevard, Wetzel Road Salina, North Medical Center, Liverpool 286 Wetzel Road 88 North SyracuseCentro Transit HUB 88: Cicero Wegmans Park-N-Ride South State Street, I-81, Brewerton Road Syracuse University, SUNY Upstate, Destiny USA, Airport Plaza Park-N-Ride, Cicero Wegmans Park-N-Ride, North Syracuse, Cicero, Central Square All 88, 188, 288, and 388 trips operate express between Downtown Syracuse and Northern Lights Plaza Select trips operate to Destiny USA 288 – Operates express between North Syracuse and Central Square