Portnov (feminine: Portnova; ) is a Russian-language occupational surname derived from the occupation of portnoy, "tailor" and literally meaning "<child> of the tailor". Sometimes written as Portnoff or Portnow.

The surname may refer to: Aleksandr Portnov, Soviet Olympic diver Andrii Portnov (born 1979), Ukrainian historian, essayist, and editor Andriy Portnov (1973–2025), Ukrainian lawyer and politician Zinaida Portnova, hero of the Soviet Union Larion Portnov, a mayor of Odesa, Ukraine