Prairie Home is an unincorporated community in Lancaster County, Nebraska, United States. The population was 38 at the 2020 census.

History In 1872, there was a post office at the location of the future town. In 1891, the village was platted by the Chicago, Rock Island, and Pacific Railroad. A 1925 edition is available for download at University of Nebraska—Lincoln Digital Commons. The town's name was derived from a farm located south of the village owned by a Mr. Waite called Prairie Home. The post office in the village stopped service in 1968.

Education It is in the Waverly School District 145.

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