The antidepressant drug doxepin has been associated with a number of different adverse effects, including the following.
The incidence of these adverse effects is not totally known as the scarcity of well-designed clinical trials involving doxepin prohibits it. Side effects that are common (based on its pharmacology or the frequency of these side effects with related agents) appear with a * superscript whereas the serious side effects are in bold. Doxepin is licensed to be used in much smaller doses (viz., 3mg and 6 mg) in some countries, the side-effects profile of which may differ from this list.
Nausea* Dizziness* Drowsiness* Dry mouth* Constipation* Blurred vision* Headache* Urinary hesitancy* Agitation* Hypotension (low blood pressure) Hypertension (high blood pressure) Tachycardia (high heart rate) Skin rash Facial oedema Photosensitisation Urticaria (hives) Pruritus (itching) Indigestion Bone fractures Taste disturbances Diarrhoea Anorexia (weight loss) Aphthous stomatitis (canker sores) Gynaecomastia (swelling of the breasts in men) Galactorrhoea (lactation that is unassociated with breast feeding or pregnancy) Chills Fatigue Weakness Flushing Alopecia (hair loss) Eosinohpilia Blood dyscrasias (abnormalities in the cellular composition of blood) Increased liver function tests Hyperpyrexia (high fever ≥41.5 °C or 106.7 °F) Seizures Confusion Malaise Increased appetite* Changes in ECG parameters (e.g. QRS & PR interval) Ataxia Hallucinations Paraesthesias Nervousness Numbness Tinnitus Hepatitis (liver swelling) Exacerbation of asthma Hepatic (liver) abnormalities Urinary retention Extrapyramidal symptoms Testicular swelling Hyperglycaemia (high blood sugar) Hypoglycaemia (low blood sugar) Hyponatraemia (low blood sodium) Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) Closed-angle glaucoma Alzheimer's disease or dementia*
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