Tsakiris () is a Greek surname. Notable people with the surname include:
Athanassios Tsakiris (born 1965), Greek biathlete and cross-country skier Constantinos Tsakiris (born 1971), Greek shipowner and banker Isabelle Tsakiris (born 1960), Australian cricketer Kai Tsakiris, American soccer player Niko Tsakiris (born 2005), American soccer player Shaun Tsakiris (born 1979), American soccer player