Northup is a surname. Notable people with the surname include:
Amos Northup (1889–1937), American automotive designer Anne Northup (born 1948), American politician Diana Northup, American biologist James M. Northup (1820–1899), New York politician Jeremiah Northup (1816–1879), Canadian merchant, shipowner, and politician Jeremiah Northup (Nova Scotia politician) (died 1809), Nova Scotia politician Harry Northup (born 1940), American actor and poet Nancy Northup (born 1960), American political activist Nate Northup (born 1981), American soccer player Oliver Northup (1925–2013), American lawyer and murder victim Solomon Northup (1808–1863), American farmer, violinist and author Stephen Northup (circa 1630–after 1687), early settler of the Colony of Rhode Island and Providence Plantations Willard C. Northup (1882–1942), American architect
See also Anson Northup, a sternwheel riverboat named for her captain Northup, Ohio, an unincorporated community founded by John S. Northup in Gallia County, Ohio, United States Northup Trail, a Louisiana Scenic Byway