Isaac Collins may refer to:
Isaac Collins (printer) (1746–1817), colonial printer, publisher, bookseller and merchant; see List of early American publishers and printers Isaac Clinton Collins (1824–1879), American politician Isaac J. Collins (1874–1975), American businessman, founder of the Anchor Hocking Isaac Collins (American football), American gridiron football coach and player Isaac Collins (baseball) (born 1997), professional baseball player