Clifton House may refer to:

United Kingdom Clifton House, Belfast, a historic building in Northern Ireland Clifton House, King's Lynn, a grade I listed building in King's Lynn, Norfolk Clifton Park and Museum, Rotherham, South Yorkshire Clifton House School, a defunct private boys' school in Harrogate, North Yorkshire, England

United States Clifton House, Pennsylvania, a historic building in Fort Washington, Pennsylvania Clifton House Site, overnight stop on the Santa Fe Trail

See also Bullock-Clifton House Clifton House Preparatory School