Sir Michael Houghton (born 1949) is a British virologist, co-discoverer of hepatitis C, and Nobel laureate.

Michael Houghton may also refer to:

Michael Houghton (bishop) (1949–1999), English Anglican priest, bishop of Ebbsfleet, 1998–1999 Mike Houghton (born 1979), American football player

See also Houghton (surname)