Santee may refer to:
People Santee (surname) Santee Smith, Canadian Mohawk artist, dancer, designer, producer and choreographer Santee Dakota, a subgroup of the Native American Dakota tribe Santee (South Carolina), a Native American tribe which once lived in South Carolina
Places in the United States Santee, California, a city Santee station, a San Diego Trolley station Santee Sioux Reservation, Nebraska Santee, Nebraska, principal village on the reservation Santee, South Carolina, a town Santee (Corbin, Virginia), a plantation home on the National Register of Historic Places Lake Santee, Indiana, a reservoir and census-designated place Santee National Wildlife Refuge, South Carolina Santee State Park, South Carolina Santee River, South Carolina Santee Canal, South Carolina, one of the earliest canals built in the United States Santee Branch, a stream in Mississippi
Other uses Santee Education Complex, Los Angeles, California Santee (film), a 1973 western starring Glenn Ford Santee (plumbing), a tee joint in a sanitation line USS Santee, various ships of the United States Navy
See also Santi (disambiguation) Santy, a computer worm released in 2004