Knutzen is a surname. Notable people with the surname include:
Egill Knutzen (1914–1990), Norwegian fencer Jan Knutzen (born 1943), Norwegian documentary filmmaker Martin Knutzen (1713–1751), German philosopher Matthias Knutzen (1646–after 1674), German atheist Thea Knutzen (1930–2016), Norwegian politician William Knutzen (1913–1983), Norwegian ceramist See also Knutzen Peak, a mountain of Ellsworth Land, Antarctica Knutzon